Evaluation of Cardiac Autonomic Nervous System Activity and Cardiopulmonary Fitness in Type 1 Diabetes: A Cross-Sectional Study

Saki, Hossein and Nazem, Farzad and Fariba, Farnaz and Khaiyat, Omid A. and Roshanaei, Ghodratollah (2025) Evaluation of Cardiac Autonomic Nervous System Activity and Cardiopulmonary Fitness in Type 1 Diabetes: A Cross-Sectional Study. International Journal of Diabetes in Developing Countries. ISSN 1998-3832 (Accepted for Publication)

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Abstract

Objectives
Autonomous nervous system (ANS) function is a valid parameter for evaluating cardiorespiratory efficiency index (VO2peak). ANS function is usually assessed through mean heart rate (HR) or heart rate variability (HRV). The aim of this study was to investigate the relationship between a range of cardiac autonomic function indices and VO2peak to assess the predictors of cardiopulmonary efficiency during rest, peak exercise performance, and recovery in adolescent males with type 1 diabetes (T1D).
Methods
This cross-sectional study recruited 60 adolescent male participants with T1D (age: 15.3 ± 1.4, mean duration of diagnosis: 6.4 ± 1). A profile of cardiac autonomic indices related to HR and HRV were measured during of rest, exercise, and recovery conditions. VO2peak was evaluated using Graded Exercise Testing (GXT).
Results
Simple linear regression models indicated a significant correlation between VO2peak and High-Frequency Power (HF) and Ratio of low to high frequency power (LF/HF) indices at rest, peak exercise, and recovery; average HR and RMSSD at rest and recovery; and Standard Deviation of all Normal R-R Intervals (SDNN) at rest (R coefficients ranged from 0.90 to 0.32, p <0.05). The multiple linear regression model indicated the HF during recovery as an independent predictor for VO2peak (R2 = 0.86, R = 0.93, p < 0.001).

Conclusion
HF appears to be a more suitable predictor of the cardiorespiratory system efficiency in the resting and recovery stages of exercise than the HR factor. The quantification of selected HRV time and frequency factors may provide clinicians with more insightful information about cardiovascular health status of adolescent with T1D during standard exercise and subsequent recovery period.

Item Type:	Article
Keywords:	Heart Rate Variability; Graded Exercise Testing; Type 1 Diabetes; Cardiorespiratory Efficiency
Faculty / Department:	Faculty of Human and Digital Sciences > School of Health and Sport Sciences
Depositing User:	Omid Khaiyat
Date Deposited:	04 Mar 2025 16:40
Last Modified:	07 Mar 2025 09:44
URI:	https://hira.hope.ac.uk/id/eprint/4630

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