Morgan, Amy E and McAuley, Mark T (2024) Vascular dementia: From pathobiology to emerging perspectives. Ageing Research Reviews. ISSN 1568-1637
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Abstract
Vascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its
symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a
substantial number of risk factors for VaD, the pathological mechanisms underpinning this disease remain to be
fully elucidated. Consequently, a biogerontological imperative exists to highlight the modifiable lifestyle factors which can mitigate against the risk of developing VaD. This review will critically examine some of the factors
which have been revealed to modulate VaD risk. The survey commences by providing an overview of the putative
mechanisms which are associated with the pathobiology of VaD. Next, the factors which influence the risk of
developing VaD are examined. Finally, emerging treatment avenues including epigenetics, the gut microbiome,
and pro-longevity pharmaceuticals are discussed. By drawing this key evidence together, it is our hope that it can
be used to inform future experimental investigations in this field.
| Item Type: | Article |
|---|---|
| Additional Information and Comments: | © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). |
| Faculty / Department: | Faculty of Human and Digital Sciences > School of Health and Sport Sciences |
| Depositing User: | Amy Morgan |
| Date Deposited: | 16 Apr 2024 10:28 |
| Last Modified: | 16 Apr 2024 10:28 |
| URI: | https://hira.hope.ac.uk/id/eprint/4184 |
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