Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation

Morgan, Amy E and Mooney, Kathleen M and Wilkinson, Steve J and Pickles, Neil A and Mc Auley, Mark T (2016) Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation. Ageing Research Reviews, 27. pp. 108-124. ISSN 1568-1637

Text Cholesterol+Metabolism+A+Review+of+How+Ageing+Disrupts+the+Biological+Mechanisms+Responsible+for+its+Regulation.docx - Accepted Version Download (831kB)

Abstract

Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between cholesterol ingestion, synthesis, absorption, and excretion. The aim of this review is to discuss how ageing interacts with these processes. Firstly, we will present an overview of cholesterol metabolism. Following this, we discuss how the biological mechanisms which underpin cholesterol metabolism are effected by ageing. Included in this discussion are lipoprotein dynamics, cholesterol absorption/synthesis and the enterohepatic circulation/synthesis of bile acids. Moreover, we discuss the role of oxidative stress in the pathological progression of atherosclerosis and also discuss how cholesterol biosynthesis is effected by both the mammalian target of rapamycin and sirtuin pathways. Next, we examine how diet and alterations to the gut microbiome can be used to mitigate the impact ageing has on cholesterol metabolism. We conclude by discussing how mathematical models of cholesterol metabolism can be used to identify therapeutic interventions.

Item Type:	Article
Additional Information and Comments:	“NOTICE: this is the author’s version of a work that was accepted for publication in Ageing Research Reviews. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Ageing Research Reviews, Vol 27, May 2016: https://doi.org/10.1016/j.arr.2016.03.008
Faculty / Department:	Faculty of Human and Digital Sciences > School of Health and Sport Sciences
Depositing User:	Amy Morgan
Date Deposited:	14 Nov 2023 10:20
Last Modified:	14 Nov 2023 10:20
URI:	https://hira.hope.ac.uk/id/eprint/4059

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