Mc Auley, Mark T and Morgan, Amy E and Mooney, Kathleen M (2017) The role of mathematical modeling in understanding aging. In: Aging: Exploring a Complex Phenomenon. CRC Press, pp. 637-652. ISBN 9780367657567
Full text not available from this repository. (Request a copy)Abstract
Mathematical models have played key roles in developing our understanding of aging. The first pioneering mathematical models evaluated aging from an evolutionary perspective, generating meaningful insights into why aging occurs and laid the foundations for our current understanding of aging. More recently mathematical models have been used to gain a deeper understanding of the intracellular mechanisms associated with intrinsic aging. This chapter will outline what mathematical modeling is, and the advantages it has over more conventional approaches used in biogerontology. The steps involved in assembling a model will also be described and the leading theoretical frameworks underpinning them will be outlined. Moreover, we discuss in detail a variety of aging focused mechanistic mathematical models which have been developed in recent years. The chapter concludes by challenging the community to develop a unified mechanistic mathematical model which can be used to examine aging in a more integrated fashion.
| Item Type: | Book Section |
|---|---|
| Faculty / Department: | Faculty of Human and Digital Sciences > School of Health and Sport Sciences |
| Depositing User: | Amy Morgan |
| Date Deposited: | 30 Oct 2023 11:32 |
| Last Modified: | 30 Oct 2023 11:32 |
| URI: | https://hira.hope.ac.uk/id/eprint/4058 |
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