The role of DNA methylation in ageing and cancer

Morgan, Amy E and Davies, Trevor J and Mc Auley, Mark T (2018) The role of DNA methylation in ageing and cancer. Proceedings of the Nutrition Society. ISSN 0029-6651

Preview

Text 157853576.pdf - Accepted Version Download (455kB) | Preview

Abstract

The aim of the present review paper is to survey the literature related to DNA methylation, and its association with cancer and ageing. The review will outline the key factors, including diet, which modulate DNA methylation. Our rationale for conducting this review is that ageing and diseases, including cancer, are often accompanied by aberrant DNA methylation, a key epigenetic process, which is crucial to the regulation of gene expression. Significantly, it has been observed that with age and certain disease states, DNA methylation status can become disrupted. For instance, a broad array of cancers are associated with promoter-specific hypermethylation and concomitant gene silencing. This review highlights that hypermethylation, and gene silencing, of the EN1 gene promoter, a crucial homeobox gene, has been detected in various forms of cancer. This has led to this region being proposed as a potential biomarker for diseases such as cancer. We conclude the review by describing a recently developed novel electrochemical method that can be used to quantify the level of methylation within the EN1 promoter and emphasise the growing trend in the use of electrochemical techniques for the detection of aberrant DNA methylation.

Item Type:	Article
Additional Information and Comments:	Copyright © The Authors 2018.
Faculty / Department:	Faculty of Human and Digital Sciences > School of Health and Sport Sciences
Depositing User:	Amy Morgan
Date Deposited:	14 Nov 2023 10:26
Last Modified:	14 Nov 2023 10:26
URI:	https://hira.hope.ac.uk/id/eprint/4056

Actions (login required)

View Item