Systems-Based Mechanisms of Aging

Proctor, Carole J and Morgan, Amy E and Mc Auley, Mark T (2019) Systems-Based Mechanisms of Aging. In: Encyclopedia of Biomedical Gerontology. Academic Press, pp. 332-345. ISBN 9780128160756

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Abstract

The last number of decades have witnessed an unrelenting global rise in the number of older people. This demographic shift is laudable; however, many older people are burdened by poor health. The main reason so many older people have their healthspan compromised is due to the complex biology which underpins aging and the diseases which are associated with this intriguing phenomenon. Fortunately, however, in recent years there has been a paradigm shift within biological research which has seen the emergence of systems biology. In contrast to a reductionist approach which was commonplace in biological research for many years, systems biology seeks to understand biological systems in an integrated manner. Investigating aging and age related disease in this way is becoming increasingly effective. In this article we discuss the methods which underpin systems approaches and provide examples of their application to biogerontology research.

Item Type:	Book Section
Faculty / Department:	Faculty of Human and Digital Sciences > School of Health and Sport Sciences
Depositing User:	Amy Morgan
Date Deposited:	06 Dec 2023 10:46
Last Modified:	06 Dec 2023 10:46
URI:	https://hira.hope.ac.uk/id/eprint/4055

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