Webb, Richard and Mazidi, Mohsen and Lip, Gregory and Kengne, Andre and Banach, Maciej and Davies, I.G. (2021) The Role of Adiposity, Diet and Inflammation on the Discordance between LDL-C and Apolipoprotein B. Nutrition, Metabolism and Cardiovascular Diseases, 32 (3). pp. 605-615. ISSN 0939-4753
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The Role of Adiposity, Diet and Inflammation on the Discordance between LDL-C and Apolipoprotein B.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Background and Aims
While low-density lipoprotein cholesterol (LDL-C) is a good predictor of atherosclerotic cardiovascular disease, apolipoprotein B (ApoB) is superior when the two markers are discordant. We aimed to determine the impact of adiposity, diet and inflammation upon ApoB and LDL-C discordance.
Methods and Results
Machine learning (ML) and structural equation models (SEMs) were applied to the National Health and Nutrition Examination Survey to investigate cardiometabolic and dietary factors when LDL-C and ApoB are concordant/discordant. Mendelian randomisation (MR) determined whether adiposity and inflammation exposures were causal of elevated/decreased LDL-C and/or ApoB. ML showed body mass index (BMI), dietary saturated fatty acids (SFA), dietary fibre, serum C-reactive protein (CRP) and uric acid were the most strongly associated variables (R2 = 0.70) in those with low LDL-C and high ApoB. SEMs revealed that fibre (b = -0.42, p = 0.001) and SFA (b = 0.28, p = 0.014) had a significant association with our outcome (joined effect of ApoB and LDL-C). BMI (b = 0.65, p = 0.001), fibre (b = -0.24, p = 0.014) and SFA (b = 0.26, p = 0.032) had significant associations with CRP. MR analysis showed genetically higher body fat percentage had a significant causal effect on ApoB (Inverse variance weighted (IVW) = Beta: 0.172, p = 0.0001) but not LDL-C (IVW = Beta: -0.006, p = 0.845).
Conclusion
Our data show increased discordance between ApoB and LDL-C is associated with cardiometabolic, clinical and dietary abnormalities and that body fat percentage is causal of elevated ApoB.
| Item Type: | Article |
|---|---|
| Additional Information and Comments: | “NOTICE: this is the author’s version of a work that was accepted for publication in Nutrition, Metabolism and Cardiovascular Diseases. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nutrition, Metabolism and Cardiovascular Diseases, Vol 32, Issue 3, March 2022. Available from: https://doi.org/10.1016/j.numecd.2021.12.004 |
| Faculty / Department: | Faculty of Human and Digital Sciences > School of Health and Sport Sciences |
| Depositing User: | Richard Webb |
| Date Deposited: | 17 Dec 2021 11:56 |
| Last Modified: | 09 Dec 2022 01:15 |
| URI: | https://hira.hope.ac.uk/id/eprint/3452 |
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