No effect of glutamine ingestion on indices of oxidative metabolism in stable COPD

Marwood, Simon and Jack, Sandy and Patel, Mukhtar and Walker, Paul and Bowtell, Joanna and Calverley, Peter (2011) No effect of glutamine ingestion on indices of oxidative metabolism in stable COPD. Respiratory Physiology & Neurobiology, 177 (1). pp. 41-46. ISSN 1569-9048

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Abstract

COPD patients have reduced muscle glutamate which may contribute to an impaired response of oxidative metabolism to exercise. We hypothesised that prior glutamine supplementation would enhance View the MathML source peak, View the MathML source at lactate threshold and speed pulmonary oxygen uptake kinetics in COPD. 13 patients (9 males, age 66 ± 5 years, mean ± SD) with severe COPD (mean FEV1 0.88 ± 0.23 l, 33 ± 7% predicted) performed on separate days ramp cycle-ergometry (5–10 W min−1) to volitional exhaustion and subsequently square-wave transitions to 80% estimated lactate threshold (LT) following consumption of either placebo (CON) or 0.125 g kg bm−1 of glutamine (GLN) in 5 ml kg bm−1 placebo. Oral glutamine had no effect on peak or View the MathML source at LT, {View the MathML source peak: CON = 0.70 ± 0.1 l min−1 vs. GLN = 0.73 ± 0.2 l min−1; LT: CON = 0.57 ± 0.1 l min−1 vs. GLN = 0.54 ± 0.1 l min−1} or View the MathML source kinetics {tau: CON = 68 ± 22 s vs. GLN = 68 ± 16 s}. Ingestion of glutamine before exercise did not improve indices of oxidative metabolism in this patient group.

Item Type:	Article
Additional Information and Comments:	NOTICE: this is the author’s version of a work that was accepted for publication in Respiratory Physiology & Neurobiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Respiratory Physiology & Neurobiology, 177 (1), 2011 DOI: 10.1016/j.resp.2011.03.010
Keywords:	Chronic obstructive pulmonary disease; Oxygen uptake kinetics; Tricarboxylic acid cycle; Glutamine; Glutamate
Subjects:	Q Science > QP Physiology
Faculty / Department:	Faculty of Human and Digital Sciences > School of Health and Sport Sciences
Depositing User:	Susan Murray
Date Deposited:	06 Mar 2014 17:16
Last Modified:	06 Mar 2014 17:16
URI:	https://hira.hope.ac.uk/id/eprint/307

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