CSF α-synuclein correlates with CSF neurogranin in late-life depression

Bruno, Davide and Plaska, Chelsea R and Clark, Daniel P A and Zetterberg, Henrik and Blennow, Kaj and Verbeek, Marcel M and Pomara, Nunzio (2020) CSF α-synuclein correlates with CSF neurogranin in late-life depression. The International Journal of Neuroscience. ISSN 0020-7454 (Accepted for Publication)

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Abstract

Major depressive disorder (MDD) in late life is linked to increased risk of subsequent dementia, but it is still unclear exactly what pathophysiological mechanisms underpin this link. A potential mechanism related to elevated risk of dementia in MDD is increased levels of α-synuclein (α-Syn), a protein found in presynaptic neuronal terminals. In this study, we examined cerebrospinal fluid (CSF) levels of α-Syn in conjunction with biomarkers of neurodegeneration (amyloid-β 42, total and phospho tau) and synaptic dysfunction (neurogranin), and measures of memory ability, in 27 cognitively intact older individuals with MDD and 19 controls. Our results show that CSF α-Syn levels did not significantly differ across depressed and control participants, but α-Syn was directly associated with neurogranin levels, and indirectly linked to poorer memory ability. All in all, we found that α-Syn may be implicated in the association between late life MDD and synaptic dysfunction, although further research is needed to confirm these results.

Item Type:	Article
Additional Information and Comments:	This is an Author's Original Manuscript of an article submitted for consideration in The International Journal of Neuroscience [copyright Taylor & Francis]; The final published version is available from: https://www.tandfonline.com/doi/full/10.1080/00207454.2020.1744596
Keywords:	α-synuclein, late-life major depressive disorder, neurogranin, memory
Faculty / Department:	Faculty of Human and Digital Sciences > School of Psychology
Depositing User:	Dan Clark
Date Deposited:	12 Mar 2020 10:27
Last Modified:	29 Jun 2020 09:15
URI:	https://hira.hope.ac.uk/id/eprint/3039

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