Sun, Zhonghua and Sultan, Aldosari and Chaichana, Thanapong (2017) An investigation of correlation between left coronary bifurcation angle and hemodynamic changes in coronary stenosis by coronary computed tomography angiography-derived computational fluid dynamics. In: The 8th International Conference on Computational Methods (ICCM2017), 25-29 July 2017, Guilin, Guangxi, China.
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Abstract
The purpose of this study was to investigate the correlation between left coronary bifurcation
angle and coronary stenosis with use of coronary CT angiography (CCTA)-generated
computational fluid dynamics (CFD) analysis when compared to the CCTA analysis of
coronary lumen stenosis with invasive coronary angiography (ICA) as the reference method.
Thirty patients with calcified plaques at the left coronary artery were included in the study
with all patients undergoing CCTA and ICA examinations. CFD simulation of left coronary
models was performed to analyze hemodynamic changes including wall shear stress, wall
pressure and flow velocity, with findings correlated to the coronary stenosis and degree of
bifurcation angle. The mean bifurcation angle was measured 83.7 ± 12.7º and 82.3 ± 11.8º on
CCTA and ICA, respectively, with no significant difference (p=0.65). Of 25 significant
stenosis at left anterior descending (LAD) and 13 at left circumflex (LCx) on CCTA, only 15
and 6 of them were confirmed to be >50% stenosis at LAD and LCx respectively on ICA.
Wall shear stress was noted to increase in the LAD and LCx models with significant stenosis
and wider angulation (>80º), but demonstrated little or no change in most of the other
coronary models with no significant stenosis and narrower angulation. Wall pressured was
decreased at the coronary arteries with significant stenosis, while flow velocity was increased
with turbulence observed at the post-stenotic sites. This study further clarifies the relationship
between left coronary bifurcation angle and significant stenosis, with angulation measurement
serving as a more accurate approach than lumen assessment for determining significant
coronary stenosis. Left coronary bifurcation angle is suggested to be incorporated into
coronary lumen assessment when diagnosing coronary artery disease.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Keywords: | Angulation, coronary artery disease, calcified plaque, computational fluid dynamics, correlation, coronary computed tomography angiography |
| Faculty / Department: | Faculty of Human and Digital Sciences > Mathematics and Computer Science |
| Depositing User: | Thanapong Chaichana |
| Date Deposited: | 24 Oct 2017 14:07 |
| Last Modified: | 24 Oct 2017 14:07 |
| URI: | https://hira.hope.ac.uk/id/eprint/2224 |
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