LIMITATIONS TO EXERCISE TOLERANCE IN TYPE 1 DIABETES: THE ROLE OF PULMONARY OXYGEN UPTAKE KINETICS AND PRIMING EXERCISE

Goulding, Richie P and Roche, Denise and Scott, Sam and Koga, Shunsaku and Weston, P.J. and Marwood, Simon (2020) LIMITATIONS TO EXERCISE TOLERANCE IN TYPE 1 DIABETES: THE ROLE OF PULMONARY OXYGEN UPTAKE KINETICS AND PRIMING EXERCISE. Journal of Applied Physiology. ISSN 8750-7587

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Abstract

We compared the time constant (τ_V ̇ O2) of the fundamental phase of pulmonary oxygen uptake (V ̇O2) kinetics between young adult males with type 1 diabetes and healthy controls. We also assessed the impact of priming exercise on τ_V ̇ O2, critical power, and muscle deoxygenation in a subset of participants with type 1 diabetes. 17 males with type 1 diabetes and 17 healthy male controls performed moderate-intensity exercise to determine τ_V ̇ O2. A subset of 7 participants with type 1 diabetes performed an additional eight visits, whereby critical power, τ_V ̇ O2 and muscle deoxyhaemoglobin + myoglobin ([HHb+Mb]; via near-infrared spectroscopy) kinetics (described by a time constant, τ[HHb+Mb]) were determined with (PRI) and without (CON) a prior 6-minute bout of heavy exercise. τ_V ̇ O2 was greater in participants with type 1 diabetes compared to controls (type 1 diabetes: 50±13 vs. control: 32±12 s; P<0.001). Critical power was greater in PRI compared to CON (PRI: 161±25 W vs. CON: 149±22 W; P<0.001), whereas τ_V ̇ O2 (PRI: 36±15 vs. CON: 50±21 s; P=0.006) and τ[HHb+Mb] (PRI: 10±5 vs. CON: 17±11 s; P=0.037) were reduced in PRI compared to CON. Type 1 diabetes patients showed slower pulmonary V ̇O2 kinetics when compared to controls; priming exercise speeded V ̇O2 and [HHb + Mb] kinetics, and increased critical power in a subgroup with type 1 diabetes. These data therefore represent the first characterisation of the power-duration relationship in type 1 diabetes, and the first experimental evidence that τ_V ̇ O2 is an independent determinant of critical power in this population.

Item Type: Article
Additional Information and Comments: This is the author's version of an article that was accepted for publication in the Journal of Applied Physiology. The final, published version is available from https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00892.2019
Keywords: critical power; exercise tolerance; muscle deoxygenation kinetics; oxygen uptake kinetics; priming exercise; type 1 diabetes
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Simon Marwood
Date Deposited: 21 May 2020 11:03
Last Modified: 21 May 2020 11:03
URI: https://hira.hope.ac.uk/id/eprint/3072

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