Computation of hemodynamics in the left coronary artery with variable angulations

Chaichana, Thanapong and Sun, Zhonghua and Jewkes, James (2011) Computation of hemodynamics in the left coronary artery with variable angulations. Journal of Biomechanics, 44 (10). pp. 1869-1878. ISSN 00219290

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The purpose of this study was to investigate the hemodynamic effect of variations in the angulations of the left coronary artery, based on simulated and realistic coronary artery models. Twelve models consisting of four realistic and eight simulated coronary artery geometries were generated with the inclusion of left main stem, left anterior descending and left circumflex branches. The simulated models included various coronary artery angulations, namely, 15°, 30°, 45°, 60°, 75°, 90°, 105° and 120°. The realistic coronary angulations were based on selected patient's data with angles ranging from narrow angles of 58° and 73° to wide angles of 110° and 120°. Computational fluid dynamics analysis was performed to simulate realistic physiological conditions that reflect the in vivo cardiac hemodynamics. The wall shear stress, wall shear stress gradient, velocity flow patterns and wall pressure were measured in simulated and realistic models during the cardiac cycle. Our results showed that a disturbed flow pattern was observed in models with wider angulations, and wall pressure was found to reduce when the flow changed from the left main stem to the bifurcated regions, based on simulated and realistic models. A low wall shear stress gradient was demonstrated at left bifurcations with wide angles. There is a direct correlation between coronary angulations and subsequent hemodynamic changes, based on realistic and simulated models. Further studies based on patients with different severities of coronary artery disease are required to verify our results.

Item Type: Article
Additional Information and Comments: Final version was published in the Journal of Biomechanics, Vol 44 (10). July 2011. Available at
Keywords: Coronary artery disease Angulation Computational fluid dynamics Wall shear stress Wall shear stress gradient
Faculty / Department: Faculty of Science > Mathematics and Computer Science
Depositing User: Thanapong Chaichana
Date Deposited: 25 Jul 2017 13:43
Last Modified: 25 Jul 2017 13:43

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