The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development.

Salcedo-Sora, J Enrique and Caamano-Gutierrez, Eva and Ward, Stephen A and Biagini, Giancarlo A (2014) The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development. Trends in parasitology, 30 (4). pp. 170-5. ISSN 1471-5007

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Abstract

We hypothesise that intraerythrocytic malaria parasite metabolism is not merely fulfilling the need for ATP generation, but is evolved to support rapid proliferation, similar to that seen in other rapidly proliferating cells such as cancer cells. Deregulated glycolytic activity coupled with impaired mitochondrial metabolism is a metabolic strategy to generate glycolytic intermediates essential for rapid biomass generation for schizogony. Further, we discuss the possibility that Plasmodium metabolism is not only a functional consequence of the 'hard-wired' genome and argue that metabolism may also have a causal role in triggering the cascade of events that leads to developmental stage transitions. This hypothesis offers a framework to rationalise the observations of aerobic glycolysis, atypical mitochondrial metabolism, and metabolic switching in nonproliferating stages.

Item Type: Article
Additional Information and Comments: “NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Parasitology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Parasitology, [VOL 30, ISSUE 4, (April 2014)] DOI#doi:10.1016/j.pt.2014.02.001¨
Keywords: Malaria Warburg effect Aerobic glycolysis Rapid proliferative cells Central carbon metabolism Plasmodium
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Enrique Salcedo-Sora
Date Deposited: 25 Feb 2016 11:37
Last Modified: 25 Feb 2016 11:37
URI: http://hira.hope.ac.uk/id/eprint/714

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