Bacterial viability on chemically modified silicon nanowire arrays

Sussary-Arce, A and Sorzabal-Bellido, I and Oknianska, A and McBride, F and Beckett, A.J and Gardeniers, J.G.E and Raval, R and Tigelaar, R.M and Diaz Fernandez, Y.A (2016) Bacterial viability on chemically modified silicon nanowire arrays. Journal of Materials Chemistry B (18). pp. 3104-3112. ISSN 2050-750X

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Alina.Materials for Biology and Medicine Article.2016.pdf - Accepted Version

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Official URL: https://pubs.rsc.org/en/content/articlelanding/201...

Abstract

The global threat of antimicrobial resistance is driving an urgent need for novel antimicrobial strategies. Functional surfaces are essential to prevent spreading of infection and reduce surface contamination. In this study we have fabricated and characterized multiscale-functional nanotopographies with three levels of functionalization: (1) nanostructure topography in the form of silicon nanowires, (2) covalent chemical modification with (3- aminopropyl)triethoxysilane, and (3) incorporation of chlorhexidine digluconate. Cell viability assays were carried out on two model microorganisms E. coli and S. aureus over these nanotopographic surfaces. Using SEM we have identified two growth modes producing distinctive multicellular structures, i.e. in plane growth for E. coli and out of plane growth for S.aureus. We have also shown that these chemically modified SiNWs arrays are effective in reducing the number of planktonic and surface-attached microorganisms.

Item Type: Article
Additional Information and Comments: This is the accepted version of an article that was published in the Journal of Materials Chemistry B. The final published version is available at http://dx.doi.org/10.1039/C6TB00460A
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Matthew Adams
Date Deposited: 22 Nov 2018 14:07
Last Modified: 22 Nov 2018 14:07
URI: http://hira.hope.ac.uk/id/eprint/2680

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