Carbohydrate oxidation and glucose utilisation under hyperglycaemia in aged and young males during exercise at the same relative exercise intensity

Malone, James J. and Bassami, Minoo and Waldron, Sarah and Campbell, Iain and Hulton, Andrew and Doran, Dominic and MacLaren, Don (2018) Carbohydrate oxidation and glucose utilisation under hyperglycaemia in aged and young males during exercise at the same relative exercise intensity. European Journal of Applied Physiology. ISSN 1439-6319 (Accepted for Publication)

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Abstract

Purpose: The purpose of the present study was to investigate the age related carbohydrate oxidation and glucose utilisation rate response during exercise at the same relative intensity under hyperglycaemia in aged and young males Methods: 16 endurance trained aged (n = 8; 69.1 ± 5.2 yr) and young (n = 8; 22.4 ± 2.9 yr) males were studied during 40 minutes of cycling exercise (60% V̇O2max) under both hyperglycaemic and euglycaemic (control) conditions. Venous blood samples were collected at baseline, post infusion, mid and post exercise. Carbohydrate and fat oxidation rates were determined at both 15 and 35 mins during exercise and glucose utilisation rates were calculated. Results: The aged group displayed significantly lower rates of carbohydrate oxidation during exercise during maintained hyperglycemia (15 mins = 2.3 ± 0.4 vs. 1.6 ± 0.5 g.min-1; 35 mins = 2.3 ± 0.5 vs. 1.5 ± 0.5 g.min-1) and control (15 mins = 2.2 ± 0.4 vs. 1.6 ± 0.7 g.min-1; 35 mins = 1.9 ± 0.7 vs. 1.3 ± 0.7 g.min-1) conditions (P = 0.01). The rate of glucose utilisation during exercise was also significantly reduced (85.76 ± 23.95 vs 56.67 ± 15.09 uM.kg-1.min-1). There were no differences between age groups for anthropometric measures, fat oxidation, insulin, glucose, NEFA, glycerol and lactate (P > 0.05), although hyperglycemia resulted in elevated glucose and insulin, and attenuated fat metabolite levels. Conclusion: Our findings highlight that ageing results in a reduction in carbohydrate oxidation and utilisation rates during exercise at the same relative exercise intensity.

Item Type: Article
Additional Information and Comments: This is the author's version of an article that was accepted for publication in the European Journal of Applied Physiology. The final, definitive version is available at https://link.springer.com/article/10.1007/s00421-018-4019-4
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Dr James Malone
Date Deposited: 25 Oct 2018 12:39
Last Modified: 25 Oct 2018 12:39
URI: http://hira.hope.ac.uk/id/eprint/2644

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