ACUTE CARDIOVASCULAR RESPONSES TO RESISTANCE EXERCISE IN ANABOLIC STEROIDS USERS: A PRELIMINARY INVESTIGATION

Angell, Peter J. and Green, Daniel J. and Lord, Rachel and Gaze, David and Whyte, Greg and George, Keith P (2018) ACUTE CARDIOVASCULAR RESPONSES TO RESISTANCE EXERCISE IN ANABOLIC STEROIDS USERS: A PRELIMINARY INVESTIGATION. Science & Sports. ISSN 0765-1597 (Accepted for Publication)

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Abstract

Objectives Anabolic steroid (AS) use has increased in recent years, but the cardiovascular consequences for users is not fully understood. Equipment and Methods Resistance trained males (AS=7, age=29±5; NAS=6, age=25±1 yrs) undertook a resistance exercise session with echocardiographic measures and cardiac biomarkers taken pre and post exercise (cTnI, NT-proBNP). Results A significant decrease in early diastolic tissue velocity (E’) (AS= 13±1 vs 11±3, NAS=13±2 vs12 ±1 cm.s-1), late diastolic tissue velocity (A’) (AS=9±2 vs 8±1, NAS= 8±1 vs 8±1 cm.s-1), E’:A’ (AS=1.63 vs 1.21, NAS= 1.71 vs 1.62) and E:A (AS=1.61 vs 1.19, NAS=1.63 vs 1.29) with an increase in late diastolic filling velocity (A) (AS=53±8 vs 65±11, NAS= 51±3 vs 57±9 cm.s-1) were seen in both groups post-exercise. A significant decrease in left ventricular end-systolic volume (LVESV) (AS=48±16 vs 45±12, NAS=51±9 vs 43±11 ml) was seen post-exercise with maintenance of ejection fraction (EF). There was a significant group effect on diastolic blood pressure (BP) (AS=74±11 vs 66±7, NAS=68±6 vs 58±2 mmHg) and basal systolic rotation rate (AS=-61.69±18.38 vs -86.65±17.99, NAS= -63.69±14.72 vs -56.50±2.15 .s-1). Conclusion Despite significant reductions in diastolic measures, with maintenance of systolic function, there was no altered cardiovascular response in the AS users following resistance exercise.

Item Type: Article
Additional Information and Comments: “NOTICE: this is the author’s version of a work that was accepted for publication in Science and Sports. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. When published, the definitive version will be available at https://doi.org/10.1016/j.scispo.2018.05.003
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Peter Angell
Date Deposited: 25 Jul 2018 13:25
Last Modified: 25 Jul 2018 13:28
URI: http://hira.hope.ac.uk/id/eprint/2581

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