Polyphenols and Their Role in Obesity Management: A Systematic Review of Randomized Clinical Trials

Farhat, Grace and Drummond, Sandra and Al-Dujaili, Emad (2017) Polyphenols and Their Role in Obesity Management: A Systematic Review of Randomized Clinical Trials. Phytotherapy research, 31 (7). pp. 1005-1018. ISSN 0951-418X

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Abstract

Polyphenols have been suggested to reduce body weight and modify body composition through different mechanisms. These effects have been extensively studied in animals and in vitro and to a lesser extent in humans. The aim of this review is to consider the association between polyphenols and body weight status by focusing on human intervention studies. We conducted a systematic literature search in MEDLINE (via EBSCOhost), ProQuest CENTRAL, and Cochrane CENTRAL without time restrictions. Randomized controlled trials assessing the effect of polyphenols on weight and/or body composition in the overweight and/or obese population were included. Nineteen studies met our inclusion criteria. Results suggest that further research is required before supporting a potential role of polyphenols in reducing weight in overweight and obese individuals (nine studies showed a significant decrease in weight by a mean of 1.47 ± 0.58 kg). Nevertheless, several studies indicated that polyphenols might be effective in preventing small increases in weight during periods of overfeeding rather than reducing weight as such. The outcomes noted do not yet support polyphenol supplementation as a complementary approach in weight loss diets. Further larger trials with a duration of 12 months or more are needed to elucidate the effect of polyphenols on body weight status.

Item Type: Article
Additional Information and Comments: This is the peer reviewed version of the following article: Farhat, G., Drummond, S., and Al-Dujaili, E. A. S. (2017) Polyphenols and Their Role in Obesity Management: A Systematic Review of Randomized Clinical Trials. Phytotherapy Research, 31 (7) pp.1005–1018, which has been published in final form at: http://onlinelibrary.wiley.com/wol1/doi/10.1002/ptr.5830/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Keywords: BMI; body fat; body weight; catechins; flavonoids; obesity; polyphenols; waist circumference
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Grace Farhat
Date Deposited: 15 Dec 2017 11:22
Last Modified: 11 May 2018 00:15
URI: http://hira.hope.ac.uk/id/eprint/2315

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