Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis

Merga, Yvette J. and O'Hara, Adrian and Burkitt, Michael D. and Duckworth, Carrie A. and Probert, Christopher S. and Campbell, Barry J. and Pritchard, D. Mark (2016) Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 310 (11). pp. 1081-1090. ISSN 0193-1857

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Official URL: http://doi.org/10.1152/ajpgi.00026.2016

Abstract

Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-κB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.

Item Type: Article
Additional Information and Comments: This is the author's version of an article that was accepted for publication in the American Journal of Physiology: Gastrointestinal and Liver Physiology, 2016. Final version available at http://ajpgi.physiology.org/content/310/11/G1081
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Adrian O'Hara
Date Deposited: 21 Nov 2017 11:16
Last Modified: 21 Nov 2017 11:16
URI: http://hira.hope.ac.uk/id/eprint/2237

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