The effects of 8-weeks concurrent training on necdin levels and insulin resistance index in obese middle-aged men.

Moghadasi, Mehrzad and Mehrabani, Javad and Momennasab, Zahra and Naderali, Ebrahim K (2017) The effects of 8-weeks concurrent training on necdin levels and insulin resistance index in obese middle-aged men. Journal of Diabetes, Metabolic Disorders & Control, 4 (1). ISSN 2374-6947 (Accepted for Publication)

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Abstract

Abstract Background: Obesity per se is a major global health problem leading to an increase in morbidity and premature mortality however increasing physical activity often results in a marked weight loss. Necdin has been shown to be an important negative regulator of adipogenesis of the white adipose tissue. We hypothesized that exercise training would impact necdin synthesis inhibiting adipocity and ultimately reducing obesity. Thus, this study was conducted to determine the effects of 8-weeks concurrent training on plasma necdin levels in obese middle-aged men. Methods: Twenty three sedentary obese middle-aged men were randomly assigned to concurrent training group (CTG: n=12) or control group (CG: n=11). The subjects in concurrent training group performed endurance and resistance training on the same days, 3 days a week, 55-65 (mean: 60) min gradually was spent over 8 weeks Results: At the end of the study, there were significant decreases in total body weight (up to 3.5 kg), body mass index (BMI; 1.2 kg/m2), waist hip ratio (WHR; 0.02 unit) and the fasting plasma insulin levels (up to 58%) and insulin resistance (HOMA-IR; P<0.05) in CTG group compared with the CG group. However, there were no significant differences in the fasting plasma levels of glucose or necdin between the two groups at the end of the study. Conclusion: Concurrent training is a viable tool in reducing body weight. There seems to be no association between 8-weeks concurrent training-induced weight loss and the total plasma necdin levels in obese middle-aged men.

Item Type: Article
Additional Information and Comments: This is an article published by MedCrave in Journal of Diabetes, Metabolic Disorders & Controlon [03/07/17], available online: http://medcraveonline.com/JDMDC/JDMDC-04-00101.pdf
Keywords: Concurrent training, Necdin, Adipocyte differentiation, Obesity, Insulin resistance
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Ebrahim Naderali
Date Deposited: 07 Apr 2017 08:59
Last Modified: 07 Apr 2017 14:54
URI: http://hira.hope.ac.uk/id/eprint/1902

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