Evaluating the Role of Birth Weight and Gestational Age on Acute Lymphoblastic Leukemia Risk Among Those of Hispanic Ethnicity.

Barahmani, Nadia and Dorak, Mehmet Tevfik and Forman, Michele R and Sprehe, Michael R and Scheurer, Michael E and Bondy, Melissa L and Okcu, M Fatih and Lupo, Philip J (2015) Evaluating the Role of Birth Weight and Gestational Age on Acute Lymphoblastic Leukemia Risk Among Those of Hispanic Ethnicity. Pediatric hematology and oncology, 32 (6). pp. 382-9. ISSN 1521-0669

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High birth weight is an established risk factor for childhood acute lymphoblastic leukemia (ALL), especially in children younger than 5 years of age at diagnosis. The goal of this study was to explore the association between being born large for gestational age and the risk for ALL by race/ethnicity to determine if the role of this risk factor differed by these characteristics. The authors compared birth certificate data of 575 children diagnosed with ALL who were younger than 5 years and included in the Texas Cancer Registry, Texas Department of Health, between the years 1995 and 2003 with 11,379 controls matched by birth year. Stratified odds ratios were calculated for risk of ALL by birth weight for gestational age, categorized in 3 groups, small, appropriate, and large for gestational age (SGA, AGA, and LGA, respectively), for each race/ethnicity group. The risk of developing ALL was higher among Hispanics who were LGA (odds ratio [OR] = 1.90, 95% confidence interval [CI]: 1.34-2.68) compared with LGA non-Hispanic whites (OR = 1.27, 95% CI: 0.87-1.86) after adjusting for infant gender, year of birth, maternal age, birth order, and presence of Down syndrome. However, the difference was not statistically significant. These results suggest that there may be differences in the association between higher growth in utero and risk of childhood ALL among Hispanics versus non-Hispanic whites.

Item Type: Article
Additional Information and Comments: This is an Accepted Manuscript of an article published by Taylor & Francis in Pediatric hematology and oncology on 3 August 2015, available online: http://wwww.tandfonline.com/10.3109/08880018.2015.1052867."
Keywords: Childhhood Acute Lymphoblastic Leukaemia Cancer Epidemiology Birth weight Ethnicity Risk markers
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Mehmet Dorak
Date Deposited: 06 Jul 2016 14:52
Last Modified: 12 Jan 2018 12:08
URI: http://hira.hope.ac.uk/id/eprint/1522

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