Haemodynamic Effect of Coronary Angulations on Subsequent Development of Coronary Artery Disease: A Preliminary Study

Chaichana, Thanapong and Sun, Zhonghua and Jewkes, James (2010) Haemodynamic Effect of Coronary Angulations on Subsequent Development of Coronary Artery Disease: A Preliminary Study. In: 2010 Sixth IEEE International Conference on e-Science Workshops. IEEE, Brisbane, pp. 39-43. ISBN 978-1-4244-8988-6

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Official URL: http://ieeexplore.ieee.org/document/5693139/

Abstract

The aim of this study is to investigate the hemodynamic effect of the angulations in the left coronary bifurcation on subsequent development of coronary artery disease. Eight 3D left coronary artery models were generated based on the anatomical details and simulated for numerical analysis. The angulations at the left coronary bifurcation were simulated with angles ranging from 120°, 105°, 90°, 75°, 60°, 45°, 30° to 15°. Computational fluid dynamic models were produced for analysis of flow velocity, wall pressure and wall shear stress. Our results showed that wide angled models produced low wall shear stress and high wall pressure at the left coronary bifurcation regions, whereas, flow pattern was more smooth and laminar with narrow angled models than those with wide angle models. Our analysis indicates the flow-field correlation between coronary angulation and development of atherosclerosis. Future studies are required to analyse the realistic coronary models from patients' data with different degree of coronary stenosis.

Item Type: Book Section
Keywords: Biology computing Cardiology Computational fluid dynamics Diseases Laminar flow Mesh generation Patient diagnosis Solid modelling
Faculty / Department: Faculty of Science > Mathematics and Computer Science
Depositing User: Thanapong Chaichana
Date Deposited: 31 Jul 2017 13:40
Last Modified: 31 Jul 2017 13:40
URI: http://hira.hope.ac.uk/id/eprint/1503

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