Birth Characteristics and Childhood Leukemia Risk: Correlations With Genetic Markers.

Kennedy, Amy E and Kamdar, Kala Y and Lupo, Philip J and Okcu, Mehmet F and Scheurer, Michael E and Dorak, Mehmet Tevfik (2015) Birth Characteristics and Childhood Leukemia Risk: Correlations With Genetic Markers. Journal of pediatric hematology/oncology, 37 (5). e301-7. ISSN 1536-3678

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Abstract

Birth characteristics such as birth order, birth weight, birth defects, and Down syndrome showed some of the first risk associations with childhood leukemia. Examinations of correlations between birth characteristics and leukemia risk markers have been limited to birth weight-related genetic polymorphisms. We integrated information on nongenetic and genetic markers by evaluating the relationship of birth characteristics, genetic markers for childhood acute lymphoblastic leukemia (ALL) susceptibility, and ALL risk together. The multiethnic study consisted of cases with childhood ALL (n=161) and healthy controls (n=261). Birth characteristic data were collected through questionnaires, and genotyping was achieved by TaqMan SNP Genotyping Assays. We observed risk associations for birth weight over 4000 g (odds ratios [OR]=1.93; 95% confidence interval [CI], 1.16-3.19), birth length (OR=1.18 per inch; 95% CI, 1.01-1.38), and with gestational age (OR=1.10 per week; 95% CI, 1.00-1.21). Only the HFE tag single-nucleotide polymorphism (SNP) rs9366637 showed an inverse correlation with a birth characteristic, gestational age, with a gene-dosage effect (P=0.005), and in interaction with a transferrin receptor rs3817672 genotype (Pinteraction=0.05). This correlation translated into a strong association for rs9366637 with preterm birth (OR=5.0; 95% CI, 1.19-20.9). Our study provides evidence for the involvement of prenatal events in the development of childhood ALL. The inverse correlation of rs9366637 with gestational age has implications on the design of HFE association studies in birth weight and childhood conditions using full-term newborns as controls.

Item Type: Article
Additional Information and Comments: This is a post-peer-review, pre-copyedited version of an article published in Journal of pediatric hematology/oncology. The definitive publisher-authenticated version Kennedy, A. E., Kamdar, K. Y., Lupo, P. J., Okcu, M. F., Scheurer, M. E., & Dorak, M. T. (2015). Birth Characteristics and Childhood Leukemia Risk: Correlations With Genetic Markers. Journal of pediatric hematology/oncology, 37(5), e301-e307. is available online at: 10.1097/MPH.0000000000000347
Keywords: Gestational Age Premature Birth Birth Weight Genetic Markers Genetic Predisposition to Disease Childhhood Acute Lymphoblastic Leukemia Genetic Association Studies
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Mehmet Dorak
Date Deposited: 23 Jun 2016 11:30
Last Modified: 01 Aug 2016 00:15
URI: http://hira.hope.ac.uk/id/eprint/1472

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