Assessment of biochemical liver markers, physical activity, fitness and body mass index for a cardiometabolic risk model in childhood

Konidari, A and Auth, MKH and Murphy, MH and Cunningham, C and Foweather, L and Gobbi, Rebecca and Graves, LEF and Hopkins, ND and Stratton, G and Boddy, LM (2014) Assessment of biochemical liver markers, physical activity, fitness and body mass index for a cardiometabolic risk model in childhood. Acta Paediatrica, 103 (5). e194-e198. ISSN 08035253

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Official URL: http://doi.org/10.1111/apa.12591

Abstract

Objective To investigate the effect of liver cell injury markers in clustered risk assessment model for identification of children at risk of cardiometabolic disease Design/Setting This cross-sectional observational study was carried out in primary schools in Liverpool and Ulster, UK. Participants were 10-12 year old healthy schoolchildren who underwent anthropometric measurements, phlebotomy, cardiorespiratory fitness and physical exercise assessments. Main outcome measures The main outcome measures included assessment of high and low cardiometabolic risk participants through a clustered risk score model, which incorporated covariates implicated in the pathogenesis of the metabolic syndrome: body mass index, waist circumference, blood pressure, proinflammatory cytokines, markers of systemic inflammation, liver cell injury markers, lipid profile, cardiorespiratory fitness and time spent in activity. Results Children classified as fit or active have lower cardiometabolic risk than their ‘unfit’ or ‘inactive’ peers. This fact remained unchanged whether markers of hepatocyte injury were included in the clustered risk assessment model or not. Conclusions The clustered risk score model is a non-invasive and scientifically robust method of cardiometabolic risk assessment in childhood, which reiterates the importance of weight reduction and promotion of cardiorespiratory fitness from childhood. Our study did not show any significant contribution of liver cell injury markers, however larger scale research is needed so as to fully evaluate the effect of these widely used markers in early cardiometabolic risk stratification in children.

Item Type: Article
Additional Information and Comments: This is the peer reviewed version of the following article: Konidari, A., Auth, M., Murphy, M., Cunningham, C., Foweather, L., Gobbi, R., Graves, L., Hopkins, N., Stratton, G. and Boddy, L. (2014), Assessment of biochemical liver markers, physical activity, fitness and body mass index for a cardiometabolic risk model in childhood. Acta Paediatrica, 103: e194–e198. doi: 10.1111/apa.12591, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/apa.12591/abstract . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Users 23 not found.
Date Deposited: 03 Jun 2016 13:10
Last Modified: 03 Jun 2016 13:10
URI: http://hira.hope.ac.uk/id/eprint/1454

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