Mathematical Modelling of Metabolic Regulation in Aging

McAuley, Mark T. and Mooney, Kathleen M and Angell, Peter J. and Wilkinson, Stephen J (2015) Mathematical Modelling of Metabolic Regulation in Aging. Metabolites, 5. pp. 232-251. ISSN 2218-1989

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Abstract

The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk between these two important pathways; however, the mechanisms underpinning their interaction(s) remains poorly understood. In this review, we propose using computational modelling in tandem with experimentation to delineate the mechanism(s). We briefly discuss the main modelling frameworks that could be used to disentangle this relationship and present a reduced reaction pathway that could be modelled. We conclude by outlining the limitations of computational modelling and by discussing opportunities for future progress in this area.

Item Type: Article
Additional Information and Comments: Published in Metabolites, Volume 5, Issue 2, DOI: 10.3390/metabo5020232 under Creative Commons Attribution Licence 4.0 (CC BY 4.0) http://creativecommons.org/licences/by/4/0/
Keywords: aging; computational modelling; mammalian target of rapamycin; systems biology; simulation; sirtuins; SIRT1; regulatory network
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Karen Foxton
Date Deposited: 25 Feb 2016 11:35
Last Modified: 27 Apr 2016 09:33
URI: http://hira.hope.ac.uk/id/eprint/775

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