Hippocampus and basal forebrain volumes modulate effects of anticholinergic treatment on delayed recall in healthy older adults.

Teipel, Stefan and Bruno, Davide and Grothe, Michel and Nierenberg, Jay and Pomara, Nunzio (2015) Hippocampus and basal forebrain volumes modulate effects of anticholinergic treatment on delayed recall in healthy older adults. Alzheimer's & Dementia: Diagnosis, Assessment and Disease Monitoring, 1 (2). pp. 216-219. ISSN 2352-8729

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Abstract

"Introduction Volumes of hippocampus and cholinergic basal forebrain are associated with delayed recall performance and may modulate the effect of a muscarinic receptor antagonist on delayed recall in healthy volunteers Methods We studied 15 older adults before and after the oral administration of a single dose of 1 or 2 mg of the preferential M1 muscarinic receptor antagonist trihexyphenidyl (Artane™) or placebo in a double-blind randomized cross-over design. Hippocampus and basal forebrain volumes were measured using magnetic resonance imaging. Results We found a significant interaction between treatment and hippocampus volume and a trend level effect between treatment and anterior basal forebrain volume on task performance, with an attenuation of the association between volume size and performance with trihexyphenidyl. Discussion These findings suggest a reduction of delayed recall performance with increasing doses of the muscarinic antagonist that is related to an uncoupling of the association of task performance with cholinergic basal forebrain and hippocampus volumes."

Item Type: Article
Additional Information and Comments: “NOTICE: this is the author’s version of a work that was accepted for publication in Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol 1, Issue 2, (June 2015), DOI# 10.1016/j.dadm.2015.01.007”
Faculty / Department: Faculty of Science > Psychology
Depositing User: Philippe Chassy
Date Deposited: 10 Jul 2015 14:40
Last Modified: 01 Jun 2016 00:15
URI: http://hira.hope.ac.uk/id/eprint/445

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