Omega-3 fatty acid supplementation and cognitive function: are smaller dosages more beneficial?

Abubakari, Abdul-Razak and Naderali, Mohmmad-Mahdi and Naderali, Ebrahim (2014) Omega-3 fatty acid supplementation and cognitive function: are smaller dosages more beneficial? International Journal of General Medicine (Int J Gen Med.), 7. pp. 463-473. ISSN 1178-7074

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Abstract

As longevity increases, so does the global prevalence of cognitive dysfunction. Numerous lifestyle and/or dietary interventions such as omega-3 fatty acids have been suggested to improve memory. Therefore, this study examined the consistency and strength of the impact of supplementation of omega-3 fatty acids on overall cognitive function using systematic reviews and meta-analytic methods. Of 905 studies retrieved from all searches, 12 randomized controlled trials were included in the meta-analysis. There were differences between studies reporting outcomes for single memory function parameters. Subgroup analysis of doses used (low versus high) indicated that subjects receiving low (<1.73 g/day) doses of omega-3 fatty acids had a significant reduction in cognitive decline rate (-0.07, 95% confidence interval -0.01, -0.02) but there was no evidence for beneficial effects at higher doses (+0.04, 95% confidence interval -0.06, +0.14) compared with the placebo group. This study suggests that omega-3 fatty acids may be beneficial in preventing memory decline at lower doses.

Item Type: Article
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Anna Kirpichnikova
Date Deposited: 02 Nov 2015 18:35
Last Modified: 29 Sep 2016 13:37
URI: http://hira.hope.ac.uk/id/eprint/437

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