Cancer: Gender differences at the molecular level

Dorak, Mehmet Tevfik (2017) Cancer: Gender differences at the molecular level. In: Principles of Gender-Specific Medicine - Gender in the Genomic Era. Elsevier Science Publishing Co Inc, San Diego, United States. ISBN 9780128035061

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Abstract

Epidemiological evidence consistently shows that males have a higher susceptibility to non-sex-specific cancers. For some cancers, the sex difference is clearly due to behavioral differences. Differences in morphology such as greater weight and height, and genetic and physiology also play a role, but exact details are missing. The differences between males and females at transcriptomics, epigenomics, proteomics, and metabolomics levels are emerging and should shed light on the mechanisms of the sex difference in cancer susceptibility. This chapter provides an overview of the epidemiologic background, differences between males and females relevant to cancer development, with a focus on gene expression and epigenetics, and specific examples of molecular mechanisms in liver and kidney cancers. Despite strong calls by agencies and journals, sex-specific analysis of research data is still only rarely done. Only more experimental data will help to gain the information about on the exact nature of this difference, which can then be used for better diagnosis and treatment.

Item Type:	Book Section
Additional Information and Comments:	Final published version available at https://www.elsevier.com/books/principles-of-gender-specific-medicine/legato/978-0-12-803506-1
Keywords:	Cancer susceptibility; cancer epidemiology; gender effect; sex ratio; sex hormones; sex chromosomes; hepatocellular cancer; renal cell cancer; sex effect; sex differential; physiology; molecular genetics
Faculty / Department:	Faculty of Human and Digital Sciences > School of Health and Sport Sciences
Depositing User:	Mehmet Dorak
Date Deposited:	25 May 2017 15:08
Last Modified:	25 May 2017 15:08
URI:	https://hira.hope.ac.uk/id/eprint/1988

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