Buchan, Duncan S. and Boddy, Lynne M and Grace, Fergal M and Brown, Elise and Sculthorpe, Nicholas and Cunningham, Conor and Murphy, Marie H. and Dagger, Rebecca. M. and Foweather, Lawrence and Graves, L. E. F. and Hopkins, Nicola D. and Stratton, Gareth and Baker, Julien S. (2016) Utility of three anthropometric indices in assessing the cardiometabolic risk profile in children. American Journal of Human Biology. ISSN 10420533 (Accepted for Publication)
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Objectives: To evaluate the ability of BMI, WC and WHtR to identify increased cardiometabolic risk in pre-adolescents. Methods: This is a cross-sectional study involving 192 children (10.92 ± 0.58 years, 56% female) from the United Kingdom between 2010 and 2013. Receiver operating characteristic curves determined the discriminatory ability of BMI, WC and WHtR to identify individuals with increased cardiometabolic risk (increased clustered triglycerides, HDL-cholesterol, systolic blood pressure, cardiorespiratory fitness and glucose). Results: A WHtR ≥ 0.5 increased the odds by 5.2 (95% confidence interval 2.6, 10.3) of having increased cardiometabolic risk. Similar associations were observed for BMI and WC. Both BMI-z and WHtR were fair predictors of increased cardiometabolic risk although BMI-z demonstrated the best trade-off between sensitivity and specificity, 76.1% and 63.6%, compared to 68.1% and 65.5% for WHtR. Cross-validation analysis revealed that BMI-z and WHtR correctly classified 84% of individuals (kappa score = 0.671, 95% CI 0.55, 0.79). The sensitivity of the cut-points suggests that 89.3% of individuals were correctly classified as being at risk with only 10.7% misdiagnosed whereas the specificity of the cut-points indicated that 77.8% of individuals were correctly identified as being healthy with 22.2% of individuals incorrectly diagnosed as being at risk. Conclusions: Findings suggest that WHtR provides similar cardiometabolic risk estimates to age and sex adjusted BMI.
|Additional Information and Comments:||This is the peer reviewed version of the following article: Buchan, D. S., Boddy, L. M., Grace, F. M., Brown, E., Sculthorpe, N., Cunningham, C., Murphy, M. H., Dagger, R., Foweather, L., Graves, L. E. F., Hopkins, N. D., Stratton, G. and Baker, J. S. (2016), Utility of three anthropometric indices in assessing the cardiometabolic risk profile in children. Am. J. Hum. Biol.. doi:10.1002/ajhb.22934, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ajhb.22934/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."|
|Keywords:||Waist-to-height ratio, cardiometabolic risk, youth, screening, adiposity.|
|Faculty / Department:||Faculty of Science > School of Health Sciences|
|Depositing User:||Becky Dagger|
|Date Deposited:||24 Nov 2016 12:42|
|Last Modified:||20 Feb 2017 13:44|
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