A meta-analysis of the associations between the SLC6A4 promoter polymorphism (5HTTLPR) and the risk for alcohol dependence.

Villalba, Karina and Attonito, Jennifer and Mendy, Angelico and Devieux, Jessy G and Gasana, Janvier and Dorak, Mehmet Tevfik (2015) A meta-analysis of the associations between the SLC6A4 promoter polymorphism (5HTTLPR) and the risk for alcohol dependence. Psychiatric genetics, 25 (2). pp. 47-58. ISSN 1473-5873

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Abstract

Serotonin reuptake variation is linked to a functional polymorphism in the promoter region of the SLC6A4 gene on chromosome 17. It is plausible that variations in genetically determined SLC6A4 activity may modify the risk for alcohol dependence. To determine whether this allele is associated with alcohol dependence, the authors conducted a systematic review and meta-analysis. Twenty-five studies including 8885 participants were reviewed and analyzed. The meta-analysis was carried out using a random-effects model. Overall, the results did not support an association between alcohol dependence and the SLC6A4 promoter polymorphism for the dominant, recessive, and additive genetic risk models, respectively [odds ratio (OR)=0.99 (95% confidence interval (CI): 0.83, 1.18), OR=0.86 (95% CI: 0.71, 1.03), and OR=0.88 (95% CI: 0.69, 1.13)]. When effect modification was tested for sex, race/ethnicity, presence/absence of a psychiatric disorder, year of publication, and diagnostic criteria, none of the factors were found to be significantly associated with alcohol dependence. The findings in this meta-analysis suggest that the SLC6A4 promoter polymorphism is not associated with alcohol dependence.

Item Type: Article
Additional Information and Comments: This is a post-peer-review, pre-copyedited version of an article published in Psychiatric Genetics. The definitive publisher-authenticated version Villalba, K., Attonito, J., Mendy, A., Devieux, J. G., Gasana, J., & Dorak, T. M. (2015). A meta-analysis of the associations between the SLC6A4 promoter polymorphism (5HTTLPR) and the risk for alcohol dependence. Psychiatric genetics, 25(2), 47-58. is available online at: 10.1097/YPG.0000000000000078
Keywords: MH - Alcoholism/*genetics MH - Case-Control Studies MH - Genetic Association Studies Polymorphism, Genetic Promoter Regions, Genetic Serotonin Plasma Membrane Transport Proteins/*genetics Genetic Epidemiology Genetic Association Studies
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Mehmet Dorak
Date Deposited: 23 Jun 2016 11:23
Last Modified: 07 Apr 2017 09:20
URI: http://hira.hope.ac.uk/id/eprint/1469

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