Neural Analyses Validate and Emphasise the Role of Progesterone Receptor in Breast Cancer Progression and Prognosis

Caronongan III, A and Venturini, B and Canuti, D and Dlay, S and Naguib, RNG and Sherbet, GV (2016) Neural Analyses Validate and Emphasise the Role of Progesterone Receptor in Breast Cancer Progression and Prognosis. Anticancer Research, 36 (4). pp. 1909-1915. ISSN 0250-7005

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Abstract

Oestrogen receptor (ER) expression is routinely measured in breast cancer management, but the clinical merits of measuring progesterone receptor (PR) expression have remained controversial. Hence the major objective here was to assess the potential of PR as a predictor of response to endocrine therapy. We report analyses of the relative importance of ER and PR for predicting prognosis using robust multilayer perceptron artificial neural networks. Receptor determinations use immunohistochemical (IHC) methods or radioactive ligand binding assays (LBA). In view of the heterogeneity of intratumoral receptor distribution, we examined the relative merits of the IHC and LBA methods. Our analyses reveal a more significant correlation of IHC-determined PR than ER with both nodal status and 5-year disease-free survival (DFS). In LBA, PR displayed higher correlation with survival and ER with nodal status. There was concordance of correlation of PR with DFS by both IHC and LBA. This study suggests a clear distinction between PR and ER, with PR displaying greater correlation than ER with disease progression and prognosis, and emphasises the marked superiority of the IHC method over LBA. These findings may be valuable in the management of patients with breast cancer.

Item Type: Article
Keywords: Breast cancer, multilayer perceptron artificial neural networks, oestrogen receptor, progesterone receptor, progression, prognosis.
Faculty / Department: Faculty of Science > Mathematics and Computer Science
Depositing User: Raouf Naguib
Date Deposited: 26 Jul 2016 13:47
Last Modified: 31 Oct 2016 01:15
URI: http://hira.hope.ac.uk/id/eprint/1386

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