Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins

Cheema, Amanpreet K. and Li, Tan and Liuzzi, Juan P. and Zarini, Gustavo G. and Dorak, Mehmet Tevfik and Huffman, Fatma G. (2015) Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins. Journal of Diabetes Research, 2015. pp. 1-10. ISSN 2314-6745

[img]
Preview
Text
Dorak_JDR.pdf

Download (1MB) | Preview
Official URL: http://doi.org/10.1155/2015/921274

Abstract

The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans ( cases and controls) and African Americans ( cases and controls) living in South Florida with and without T2D. Adjusted logistic regression indicated that both SNP rs7656250 (OR = 0.22, ) and rs4235308 (OR = 0.42, ) showed protective association with T2D in Haitian Americans. In African Americans, however, rs4235308 showed significant risk association with T2D (OR = 2.53, ). After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, ) and rs7656250 (OR = 0.23, ) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, ). The trends observed for genetic association of PPARGC1A SNPs, rs4235308, and rs7656250 for T2D between Haitian Americans and African Americans point out differences in Black race and warrant replicative study with larger sample size.

Item Type: Article
Keywords: Genetic predisposition to disease, genetic association study, type 2 diabetes, ethnicity, single nucleotide polymorphism, gender effect
Faculty / Department: Faculty of Science > School of Health Sciences
Depositing User: Mehmet Dorak
Date Deposited: 26 Apr 2016 13:56
Last Modified: 28 Sep 2016 13:49
URI: http://hira.hope.ac.uk/id/eprint/1279

Actions (login required)

View Item View Item